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Roflumilast N-oxide

CAS No. 292135-78-5

Roflumilast N-oxide ( Roflumilast N-oxide )

Catalog No. M18375 CAS No. 292135-78-5

Roflumilast N-oxide is a PDE type 4 inhibitor.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Roflumilast N-oxide
  • Note
    Research use only, not for human use.
  • Brief Description
    Roflumilast N-oxide is a PDE type 4 inhibitor.
  • Description
    Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Roflumilast N-oxide is the active metabolite of roflumilast. Roflumilast N-Oxide in Combination with Formoterol Enhances the Antiinflammatory Effect of Dexamethasone in Airway Smooth Muscle Cells. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.
  • Synonyms
    Roflumilast N-oxide
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    PDE4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    292135-78-5
  • Formula Weight
    419.21
  • Molecular Formula
    C17H14Cl2F2N2O4
  • Purity
    98%
  • Solubility
    DMSO : 320 mg/mL 763.34 mM;
  • SMILES
    Clc3c[n+]([O-])cc(Cl)c3NC(=O)c2ccc(OC(F)F)c(OCC1CC1)c2
  • Chemical Name
    N-(3,5-Dichloro-1-oxopyridin-4-yl)-4-difluoromethoxy-3-cyclopropylmethoxybenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Victoni T,etal.Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.Int Immunopharmacol. 2016 Jan;30:1-8.
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